abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...

journal_title：Thrombosis research

authors： Khan N,Cox AR,Cotton JM

更新日期：2016-07-01 00:00:00

abstract：:A 79-year-old lean man with a height of 157cm and weight of 42kg (body mass index, 17.2kg/m(2)) receiving rivaroxaban developed an intracranial subdural hematoma and was treated conservatively. Because he had a reduced creatinine clearance of 44mL/min, his dosage of rivaroxaban was reduced from 15 to 10mg daily accord...

journal_title：Thrombosis research

authors： Yamaguchi Y,Koga M,Matsuki T,Hino T,Yokota C,Toyoda K

更新日期：2016-07-01 00:00:00

abstract：:An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AFib hemodynamic shear stress patterns to primary human endothelial cel...

journal_title：Thrombosis research

authors： Simmers MB,Cole BK,Ogletree ML,Chen Z,Xu Y,Kong LJ,Mackman N,Blackman BR,Wamhoff BR

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to investigate whether long-term use of LMWH during pregnancy is associated wi...

journal_title：Thrombosis research

authors： Galambosi P,Hiilesmaa V,Ulander VM,Laitinen L,Tiitinen A,Kaaja R

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:A poor implementation of VTE prophylactic measures recommended for critically ill patients has been observed in several epidemiological studies. The clinical factors associated with this have not been clearly established. The objective of our study was to identify which factors could be related to the inappropr...

journal_title：Thrombosis research

authors： García-Olivares P,Guerrero JE,Keough E,Galdos P,Carriedo D,Murillo F,Rivera A,PROF-ETEV study investigators.

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:The standard dabigatran etexilate dosage for prevention of venous thromboembolism (VTE) after elective total hip or knee replacement (THR/TKR) is 220mg once daily (qd), with 150mg qd for patients with moderate renal impairment. As clinical trial experience in patients with moderate renal impairment was lim...

journal_title：Thrombosis research

authors： Samama CM,Rosencher N,Kleine E,Feuring M,Brueckmann M,Clemens A,Gullberg J,Frostick SP

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Coronary collateral circulation (CCC) plays an important role in protecting myocardium from ischemic damage. The studies on factors which impact on CCC might be of great clinical interest. The aim of the present study was to evaluate endothelin-1 (ET-1) as a potential predictor for poor or good CCC in patien...

journal_title：Thrombosis research

authors： Fan Y,Li S,Li XL,Lin XL,Zhu CG,Xu RX,Qing P,Wu NQ,Jiang LX,Xu B,Gao RL,Li JJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common complication of acute stroke, but the new incidence in the era of improved specialist input in stroke care is yet unknown. The models for VTE diagnosis is well established, but prediction models to target at-risk patients for pharmacological prophylaxis is lacking and r...

journal_title：Thrombosis research

authors： Balogun IO,Roberts LN,Patel R,Pathansali R,Kalra L,Arya R

更新日期：2016-06-01 00:00:00

abstract：:The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...

journal_title：Thrombosis research

authors： Hoffmeister KM,Falet H

更新日期：2016-05-01 00:00:00

abstract：:There are some issues in the current factor (F)VIII replacement therapy for severe hemophilia A. One is mental and physical burden for the multiple intravenous infusions, and the other is difficulty in the hemostatic treatment for the patients with FVIII inhibitor. The development of novel drug with fully hemostatic e...

journal_title：Thrombosis research

authors： Nogami K

更新日期：2016-05-01 00:00:00

abstract：AIM:Postprandial platelet activation was related to postprandial insulin rather than glucose levels in a previous meal insulin study in type 2 diabetes mellitus (T2DM). We therefore compared postprandial platelet activation in type 1 (T1DM) patients without insulin secretion and T2DM patients with high postprandial ins...

journal_title：Thrombosis research

authors： Spectre G,Stålesen R,Östenson CG,Hjemdahl P

更新日期：2016-05-01 00:00:00

abstract：:Studies with animal models implicate the plasma proteases factor XIIa (FXIIa) and α-kallikrein in arterial and venous thrombosis. As congenital deficiencies of factor XII (FXII) or prekallikrein (PK), the zymogens of FXIIa and α-kallikrein respectively, do not cause bleeding disorders, inhibition of these enzymes may ...

journal_title：Thrombosis research

authors： Kokoye Y,Ivanov I,Cheng Q,Matafonov A,Dickeson SK,Mason S,Sexton DJ,Renné T,McCrae K,Feener EP,Gailani D

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...

journal_title：Thrombosis research

authors： Krag AE,Kiil BJ,Hvas CL,Eschen GT,Hvas AM

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Tissue factor (TF) is abnormally expressed in many cancers including colorectal and is associated with a poor cancer prognosis. Colorectal cancer cell lines expressing TF produce faster growing tumours. In lung cancer, TF inhibition has been shown to reduce proliferation AIM:We aimed to determine if TF ex...

journal_title：Thrombosis research

authors： Clouston HW,Lamb R,Duff S,Kirwan CC

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Tissue Factor Pathway Inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor whose expression is up-regulated by VEGF in microvascular and umbilical vein endothelial cells (EC). Despite this, TFPI-2 has been suggested as anti-angiogenic molecule, due to its ability to inhibit the migration/proli...

journal_title：Thrombosis research

authors： Ghilardi C,Anastasia A,Avigni R,Lupi M,Giavazzi R,Bani MR

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Lung cancer is the leading cause of cancer-related death worldwide. Small cell lung cancer (SCLC) is thereby a highly aggressive neuroendocrine carcinoma representing about 15% of all lung cancer cases. Due to the highly metastatic behavior and multidrug resistance, the long-term survival of patients is ve...

journal_title：Thrombosis research

authors： Taromi S,Catusse J,Elverfeldt DV,Reichardt W,Ledig B,Zeiser R,Burger M

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Ductal carcinoma in-situ (DCIS) is a preinvasive breast cancer where cancer cells remain confined within the ductal basement membrane. However, genotypic changes have been identified in stroma surrounding DCIS, outside the basement membrane. Stromal fibroblasts undergo phenotypic change in cancer to promot...

journal_title：Thrombosis research

authors： Shaker H,Bundred NJ,Albadry H,Nicholson S,Castle J,Lumsden LJ,Pritchard S,Landberg G,Kirwan CC

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Metastases are responsible for more than 90% of cancer related mortality. The hematogenous metastatic invasion is a complex process in which the endothelium plays a key role. Extravasation is a dynamic process involving remodeling and change in cell shape and in cytoskeleton whereby a series of strongly de...

journal_title：Thrombosis research

authors： Gilardi M,Bersini S,Calleja AB,Kamm RD,Vanoni M,Moretti M

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Prediction of venous thromboembolism (VTE) occurrence in cancer patients using individual risk factors may contribute to preventing the burden of disease associated with VTE. Congestive heart failure in patients with cancer may increase the risk of VTE and worsen the prognosis. AIM:We sought to investigat...

journal_title：Thrombosis research

authors： Königsbrügge O,Riedl J,Grilz E,Wiltschke C,Zielinski C,Pabinger I,Ay C

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Severe thrombocytopenia (≤50×10(9) platelets/L) is often the consequence of hematological malignancies and intensive chemotherapy. The risk of clinically significant bleeding is increased in these patients, despite the use of prophylactic platelet transfusions. The fact that there is no clear correlation b...

journal_title：Thrombosis research

authors： Baaten CC,Moenen FC,Henskens YM,Swieringa F,Wetzels R,van Oerle R,Ten Cate H,Beckers EA,Heemskerk JW,van der Meijden PE

更新日期：2016-04-01 00:00:00

abstract：:Both venous thromboembolism and intracranial metastases are common complications in the setting of primary brain tumors and metastatic malignancies. Anticoagulation is indicated in the presence of cancer-associated thrombosis in order to limit the risk of pulmonary embolism; however, there is reluctance to initiate an...

journal_title：Thrombosis research

authors： Weinstock MJ,Uhlmann EJ,Zwicker JI

更新日期：2016-04-01 00:00:00

abstract：:Whilst the term cancer associated thrombosis (CAT) offers an overarching term for all thrombotic events encountered during the cancer journey, the reality is that this is a far too simplistic reflection of a complex multifactorial process occurring within a heterogeneous population. The management of CAT needs to cons...

journal_title：Thrombosis research

authors： Noble S,Sui J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The diagnostic work-up for heparin induced thrombocytopenia (HIT) can take several days. Consequently patients may be speculatively switched onto replacement anticoagulant therapy before a diagnosis is confirmed. On-demand immunoassay diagnostic testing enables timely treatment decisions, based on test resul...

journal_title：Thrombosis research

authors： Caton S,O'Brien E,Pannelay AJ,Cook RG

更新日期：2016-04-01 00:00:00

abstract：:Major orthopaedic surgery is associated with an increased risk of venous thromboembolism. Direct oral anticoagulants (DOACs) are recommended as thromboprophylactic agents after orthopaedic surgery. Although routine monitoring of DOACs in general is not required, measuring DOAC concentration may be necessary in clinica...

journal_title：Thrombosis research

authors： Schellings MW,Boonen K,Schmitz EM,Jonkers F,van den Heuvel DJ,Besselaar A,Hendriks JG,van de Kerkhof D

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Critical care patients are prone to venous thromboembolism (VTE) and, thus, pharmacological thromboprophylaxis is generally advised. Low-molecular weight heparins (LMWHs) have become the drug of choice in ICU patients, since their predictable and reproducible dose response. Monitoring their pharmacological e...

journal_title：Thrombosis research

authors： Vahtera A,Vaara S,Pettilä V,Kuitunen A

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:We showed previously that the prothrombotic effect of one hour aldosterone (ALDO) infusion in rats was only partially mediated by the mineralocorticoid receptor (MR). Bearing in mind that ALDO potentiates the effects of angiotensin II (Ang II), in the present study we investigated the role of Ang II recept...

journal_title：Thrombosis research

authors： Gromotowicz-Poplawska A,Stankiewicz A,Kramkowski K,Gradzka A,Wojewodzka-Zelezniakowicz M,Dzieciol J,Szemraj J,Chabielska E

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Tissue factor pathway inhibitor-2 (TFPI-2) regulates matrix metalloproteinases activation and extracellular matrix degradation. Over-expression of TFPI-2 enhances atherosclerotic plaque stability. The aim of this study is to investigate the effect of conditional knockout (KO) of TFPI-2 in vascular endothelia...

journal_title：Thrombosis research

authors： Hong J,Liu R,Chen L,Wu B,Yu J,Gao W,Pan J,Luo X,Shi H

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Post-thrombotic syndrome (PTS) is a chronic sequel of deep vein thrombosis (DVT). The clot structure and fibrinolytic potential in PTS is currently unknown. OBJECTIVE:To assess the fibrinolytic potential and clot structure in patients with PTS. MATERIALS AND METHODS:Patients with a history of DVT were in...

journal_title：Thrombosis research

authors： Bouman AC,McPherson H,Cheung YW,Ten Wolde M,Ten Cate H,Ariëns RAS,Ten Cate-Hoek AJ

更新日期：2016-01-01 00:00:00

abstract：:Central venous catheter-related thrombosis (CRT) is a complication seen in patients requiring long-term intravenous access. Treatment of CRT is not standardized and international guidelines for treatment are based on extrapolation of evidence from lower extremity thrombosis. We performed a systematic review of the lit...

journal_title：Thrombosis research

authors： Baumann Kreuziger L,Onwuemene O,Kolesar E,Crowther M,Lim W

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Antiphospholipid syndrome (APS) is a pro-thrombotic autoimmune disease that affects different vascular beds, with potential risk for recurrence. Systemic lupus erythematosus (SLE), specific autoantibodies profile and atherogenic disorders have been described as risk factors for the occurrence of first thro...

journal_title：Thrombosis research

authors： Saraiva Sda S,Custódio IF,Mazetto Bde M,Collela MP,de Paula EV,Appenzeller S,Annichino-Bizzachi J,Orsi FA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:By using endovascular techniques, we set up an animal model of mesenteric venous thrombosis to avoid surgical laparotomy. MATERIALS AND METHODS:Ten pigs underwent percutaneous transhepatic puncture to create animal model of acute superior mesenteric venous thrombosis. Experimental animals were injected with th...

journal_title：Thrombosis research

authors： Kai L,Jiaxiang M,Xinxin F,Baochen L,Weiwei D,Xingjiang W,Shuofei Y,Jieshou L

更新日期：2015-12-01 00:00:00

abstract：:Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

journal_title：Thrombosis research

authors： Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

更新日期：2015-12-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a preventable disease, yet it is one of the leading causes of death among patients with cancer. Improving risk stratification mechanisms will allow us to personalize thrombo-prophylaxis strategies. We sought to evaluate Collagen and Thrombin Activated Platelets (COAT-platelets) as well ...

journal_title：Thrombosis research

authors： Tafur AJ,Dale G,Cherry M,Wren JD,Mansfield AS,Comp P,Rathbun S,Stoner JA

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Administrative data can be used to identify venous thromboembolism (VTE) and major bleeding (MB) events. However, the validity of this data in emergency room discharge records in Canada is unknown. METHODS:We conducted a single-institution retrospective chart re-abstraction study in London, Canada. We ident...

journal_title：Thrombosis research

authors： Al-Ani F,Shariff S,Siqueira L,Seyam A,Lazo-Langner A

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA). METHODS:We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing the risk of VTE i...

journal_title：Thrombosis research

authors： Ungprasert P,Tanratana P,Srivali N

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of ev...

journal_title：Thrombosis research

authors： Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJ

更新日期：2015-11-01 00:00:00

abstract：:This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of...

journal_title：Thrombosis research

authors： Lee SE,Jeon YW,Yoon JH,Cho BS,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Kim DW,Lee JW,Min WS,Kim M,Min CK

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Although risk of hospital-associated venous thromboembolism (HA-VTE) differs between critically and non-critically ill children, studies to date have not led to distinct, pragmatic risk scores. OBJECTIVE:To determine risk factors for HA-VTE in critically ill children not undergoing cardiothoracic surgery, i...

journal_title：Thrombosis research

authors： Arlikar SJ,Atchison CM,Amankwah EK,Ayala IA,Barrett LA,Branchford BR,Streiff MB,Takemoto CM,Goldenberg NA

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:An association between high red cell distribution width (RDW) and venous thromboembolism (VTE) has been observed. However, it is not known whether this association differs within various manifestations of VTE, nor if there is an interaction between RDW and thrombophilia abnormalities on the risk of VTE. AIM...

journal_title：Thrombosis research

authors： Bucciarelli P,Maino A,Felicetta I,Abbattista M,Passamonti SM,Artoni A,Martinelli I

更新日期：2015-09-01 00:00:00